How to watch San Francisco 49ers vs. Seattle Seahawks: TV channel, streaming info
The 49ers and the Seahawks play at 8:15 p.m. ET. Spread favorite: 49ers (-3.5) Over their last five meetings, San Francisco has totaled five wins against Seattle. The last five times the 49ers have gone up against the Seahawks, they have posted a 4-1 record against the spread. The scoring has gone over the total on two occasions.